Novel Biodegradable Polymeric Microparticles Facilitate Scarless Wound Healing by Promoting Re-epithelialization and Inhibiting Fibrosis
نویسندگان
چکیده
منابع مشابه
Wound re-epithelialization: modulating keratinocyte migration in wound healing.
An essential feature of a healed wound is the restoration of an intact epidermal barrier through wound epithelialization, also known as re-epithelialization. The directed migration of keratinocytes is critical to wound epithelialization and defects in this function are associated with the clinical phenotype of chronic non-healing wounds. A complex balance of signaling factors and surface protei...
متن کاملAdvances in Scarless Wound Healing
Wound care is a perennial burden for the US healthcare system, costing an estimated $25 billion annually for the treatment of chronic wounds alone [1]. Problems surrounding scarring have also created a $12 billion market annually for treatment [2]. In the 1979 landmark study, Rowlatt et al. reported that human fetal wound healing did not cause scar formation [3]. Animal models were subsequently...
متن کاملRe-epithelialization: advancing epithelium frontier during wound healing
The first function of the skin is to serve as a protective barrier against the environment. Its loss of integrity as a result of injury or illness may lead to a major disability and the first goal of healing is wound closure involving many biological processes for repair and tissue regeneration. In vivo wound healing has four phases, one of them being the migration of the healthy epithelium sur...
متن کاملPolymeric Sustained Biodegradable Patch Formulation for Wound Healing
It is the patient compliance and stability in combination with controlled drug delivery and biocompatibility that forms the core feature in present research and development of sustained biodegradable patch formulation intended for wound healing. The aim was to impart sustained degradation, sterile formulation, significant folding endurance, elasticity, biodegradability, bio-acceptability and st...
متن کاملScarless wound healing in the mammalian fetus.
Fetal wound healing is a remarkable process that is fundamentally different than postnatal healing. Healing of primarily closed, linear wounds occurs rapidly and without scarring. In late gestational age fetal sheep, a transition to adult-like healing occurs as evidenced by minimal scar formation. Acute inflammation is not involved, fibroblast recruitment and proliferation is minimal, the matri...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2018
ISSN: 1664-3224
DOI: 10.3389/fimmu.2018.02851